Pub. Date : 2008 Dec
PMID : 18989785
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Involvement of endoplasmic reticulum stress in Docetaxel-induced JNK-dependent apoptosis of human melanoma. | Docetaxel | mitogen-activated protein kinase 8 | Homo sapiens |
| 2 | Our previous studies revealed that Docetaxel-induced apoptosis of melanoma cells is entirely dependent on activation of the JNK signalling pathway. | Docetaxel | mitogen-activated protein kinase 8 | Homo sapiens |
| 3 | Knockdown of IRE1alpha by siRNA markedly inhibited Docetaxel-induced JNK activation and downstream targets of JNK indicating that activation of IRE1alpha was upstream of activation of the JNK. | Docetaxel | mitogen-activated protein kinase 8 | Homo sapiens |
| 4 | Knockdown of IRE1alpha by siRNA markedly inhibited Docetaxel-induced JNK activation and downstream targets of JNK indicating that activation of IRE1alpha was upstream of activation of the JNK. | Docetaxel | mitogen-activated protein kinase 8 | Homo sapiens |
| 5 | Knockdown of IRE1alpha by siRNA markedly inhibited Docetaxel-induced JNK activation and downstream targets of JNK indicating that activation of IRE1alpha was upstream of activation of the JNK. | Docetaxel | mitogen-activated protein kinase 8 | Homo sapiens |
| 6 | ER stress mediated activation of the JNK pathway is downstream of activation of PKCdelta in that downregulation of PKCdelta expression using specific PKCdelta siRNA significantly inhibited Docetaxel-induced activation of IRE1alpha and the JNK pathway. | Docetaxel | mitogen-activated protein kinase 8 | Homo sapiens |
| 7 | ER stress mediated activation of the JNK pathway is downstream of activation of PKCdelta in that downregulation of PKCdelta expression using specific PKCdelta siRNA significantly inhibited Docetaxel-induced activation of IRE1alpha and the JNK pathway. | Docetaxel | mitogen-activated protein kinase 8 | Homo sapiens |