Title : Regulation of IGFBP6 gene and protein is mediated by the inverse expression and function of c-jun N-terminal kinase (JNK) and NFkappaB in a model of oral tumor cells.

Pub. Date : 2008 Dec

PMID : 18982452






3 Functional Relationships(s)
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1 In addition, increased expression of JNK in the absence of NFkappaB resulted in a significant induction of cell death in oral tumors when either left untreated or treated with TNF-alpha and TPA. Tetradecanoylphorbol Acetate mitogen-activated protein kinase 8 Homo sapiens
2 Moreover, when JNK was inhibited by dominant negative JNK (APF), a significant decrease in cell death could be observed in TNF-alpha and TPA treated NFkappaB knock down oral tumors. Tetradecanoylphorbol Acetate mitogen-activated protein kinase 8 Homo sapiens
3 Moreover, when JNK was inhibited by dominant negative JNK (APF), a significant decrease in cell death could be observed in TNF-alpha and TPA treated NFkappaB knock down oral tumors. Tetradecanoylphorbol Acetate mitogen-activated protein kinase 8 Homo sapiens