Pub. Date : 2008 Sep 24
PMID : 18815253
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Region-specific changes in the subcellular distribution of AMPA receptor GluR1 subunit in the rat ventral tegmental area after acute or chronic morphine administration. | Morphine | glutamate ionotropic receptor AMPA type subunit 1 | Rattus norvegicus |
| 2 | Indeed, chronic morphine administration is known to increase AMPA receptor glutamate receptor 1 (GluR1) subunit in the VTA. | Morphine | glutamate ionotropic receptor AMPA type subunit 1 | Rattus norvegicus |
| 3 | Indeed, chronic morphine administration is known to increase AMPA receptor glutamate receptor 1 (GluR1) subunit in the VTA. | Morphine | glutamate ionotropic receptor AMPA type subunit 1 | Rattus norvegicus |
| 4 | Acute morphine administration produced a significant increase in GluR1 immunogold particles at the plasma membrane and postsynaptic densities in both TH- and non-TH-containing dendrites in the parabrachial VTA, a region that contains mainly prefrontal-cortical-projecting dopaminergic neurons involved in motivation and drug-seeking behavior. | Morphine | glutamate ionotropic receptor AMPA type subunit 1 | Rattus norvegicus |
| 5 | Chronic morphine administration maintained the increased synaptic GluR1 labeling in the parabrachial VTA, but also increased the number of GluR1-labeled synapses and TH immunoreactivity in dendrites of the paranigral VTA where substantially more dopaminergic neurons project to limbic structures implicated in locomotor activation and reward. | Morphine | glutamate ionotropic receptor AMPA type subunit 1 | Rattus norvegicus |
| 6 | Chronic morphine administration maintained the increased synaptic GluR1 labeling in the parabrachial VTA, but also increased the number of GluR1-labeled synapses and TH immunoreactivity in dendrites of the paranigral VTA where substantially more dopaminergic neurons project to limbic structures implicated in locomotor activation and reward. | Morphine | glutamate ionotropic receptor AMPA type subunit 1 | Rattus norvegicus |
| 7 | These results demonstrate a region- and dose-dependent redistribution of GluR1-containing AMPA receptors, which is consistent with acute morphine activation of cortical-projecting VTA neurons and chronic morphine activation of limbic-projecting VTA neurons. | Morphine | glutamate ionotropic receptor AMPA type subunit 1 | Rattus norvegicus |
| 8 | These results demonstrate a region- and dose-dependent redistribution of GluR1-containing AMPA receptors, which is consistent with acute morphine activation of cortical-projecting VTA neurons and chronic morphine activation of limbic-projecting VTA neurons. | Morphine | glutamate ionotropic receptor AMPA type subunit 1 | Rattus norvegicus |