Title : Nicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone induce cyclooxygenase-2 activity in human gastric cancer cells: Involvement of nicotinic acetylcholine receptor (nAChR) and beta-adrenergic receptor signaling pathways.

Pub. Date : 2008 Dec 1

PMID : 18805435






3 Functional Relationships(s)
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1 Nicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone induce cyclooxygenase-2 activity in human gastric cancer cells: Involvement of nicotinic acetylcholine receptor (nAChR) and beta-adrenergic receptor signaling pathways. Nicotine prostaglandin-endoperoxide synthase 2 Homo sapiens
2 In addition, nicotine and NNK mediated COX-2 induction via different receptors to modulate several G1/S transition regulatory proteins and promote gastric cancer cell growth. Nicotine prostaglandin-endoperoxide synthase 2 Homo sapiens
3 Selective COX-2 inhibitor (SC-236) caused G1 arrest and abrogated nicotine/NNK-induced cell proliferation. Nicotine prostaglandin-endoperoxide synthase 2 Homo sapiens