PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
18805435-0	2008	Nicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone induce cyclooxygenase-2 activity in human gastric cancer cells: Involvement of nicotinic acetylcholine receptor (nAChR) and beta-adrenergic receptor signaling pathways.	Nicotine	0-8	prostaglandin-endoperoxide synthase 2	Homo sapiens	67-83	
18805435-7	2008	In addition, nicotine and NNK mediated COX-2 induction via different receptors to modulate several G1/S transition regulatory proteins and promote gastric cancer cell growth.	Nicotine	13-21	prostaglandin-endoperoxide synthase 2	Homo sapiens	39-44	
18805435-8	2008	Selective COX-2 inhibitor (SC-236) caused G1 arrest and abrogated nicotine/NNK-induced cell proliferation.	Nicotine	66-74	prostaglandin-endoperoxide synthase 2	Homo sapiens	10-15