Pub. Date : 2009 Aug
PMID : 18767140
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Activation of JNK and PAK2 is essential for citrinin-induced apoptosis in a human osteoblast cell line. | Citrinin | mitogen-activated protein kinase 8 | Homo sapiens |
| 2 | CTN induced apoptotic biochemical changes in a human osteoblast cell line, including activation of c-Jun N-terminal kinase (JNK), loss of mitochondrial membrane potential, and caspase-3 and p21-activated protein kinase 2 (PAK2) activation. | Citrinin | mitogen-activated protein kinase 8 | Homo sapiens |
| 3 | CTN induced apoptotic biochemical changes in a human osteoblast cell line, including activation of c-Jun N-terminal kinase (JNK), loss of mitochondrial membrane potential, and caspase-3 and p21-activated protein kinase 2 (PAK2) activation. | Citrinin | mitogen-activated protein kinase 8 | Homo sapiens |
| 4 | Experiments using a JNK-specific inhibitor, SP600125, and antisense oligonucleotides against JNK reduced CTN-induced activation of both JNK and caspase-3 in osteoblasts, indicating that JNK is required for caspase activation in this apoptotic pathway. | Citrinin | mitogen-activated protein kinase 8 | Homo sapiens |
| 5 | Experiments using a JNK-specific inhibitor, SP600125, and antisense oligonucleotides against JNK reduced CTN-induced activation of both JNK and caspase-3 in osteoblasts, indicating that JNK is required for caspase activation in this apoptotic pathway. | Citrinin | mitogen-activated protein kinase 8 | Homo sapiens |
| 6 | Experiments using a JNK-specific inhibitor, SP600125, and antisense oligonucleotides against JNK reduced CTN-induced activation of both JNK and caspase-3 in osteoblasts, indicating that JNK is required for caspase activation in this apoptotic pathway. | Citrinin | mitogen-activated protein kinase 8 | Homo sapiens |
| 7 | Experiments using a JNK-specific inhibitor, SP600125, and antisense oligonucleotides against JNK reduced CTN-induced activation of both JNK and caspase-3 in osteoblasts, indicating that JNK is required for caspase activation in this apoptotic pathway. | Citrinin | mitogen-activated protein kinase 8 | Homo sapiens |
| 8 | On the basis of these results, we propose a signaling cascade model for CTN-induced apoptosis in human osteoblasts involving ROS, JNK, caspases, and PAK2. | Citrinin | mitogen-activated protein kinase 8 | Homo sapiens |