Title : Platelets undergo phosphorylation of Syk at Y525/526 and Y352 in response to pathophysiological shear stress.

Pub. Date : 2008 Oct

PMID : 18715989






1 Functional Relationships(s)
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1 Increased phosphorylation at both sites was attenuated by pharmacological inhibition of Syk using two different Syk inhibitors, piceatannol and 3-(1-methyl-1H-indol-3-yl-methylene)-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide (OXSI-2), and by inhibition of upstream Src-family kinases (SFKs). 3,3',4,5'-tetrahydroxystilbene spleen associated tyrosine kinase Homo sapiens