Title : Rhenium and technetium complexes bearing quinazoline derivatives: progress towards a 99mTc biomarker for EGFR-TK imaging.

Pub. Date : 2008 Jun 28

PMID : 18688420






2 Functional Relationships(s)
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1 Rhenium and technetium complexes bearing quinazoline derivatives: progress towards a 99mTc biomarker for EGFR-TK imaging. Quinazolines epidermal growth factor receptor Homo sapiens
2 In vitro studies indicate that the quinazoline fragments, after conjugation to the cyano group (L1, L2) or to the pyrazolyl containing chelator (L5H), as well as the corresponding Re complexes (7, 8, 10) inhibit significantly the EGFR autophosphorylation and also inhibit A431 cell growth. Quinazolines epidermal growth factor receptor Homo sapiens