Title : Oxidative stress plays a critical role in inactivating mutant BRAF by geldanamycin derivatives.

Pub. Date : 2008 Aug 1

PMID : 18676857






1 Functional Relationships(s)
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1 Previous studies have shown that 17-AAG/DMAG treatment induces the degradation of mutant BRAF (V600E) and inhibits the activation of mitogen-activated protein/extracellular signal-regulated kinase 1/2 (MEK1/2). tanespimycin B-Raf proto-oncogene, serine/threonine kinase Homo sapiens