Title : Fos expression following activation of the ventral pallidum in normal rats and in a model of Parkinson's Disease: implications for limbic system and basal ganglia interactions.

Pub. Date : 2008 Sep

PMID : 18663473






2 Functional Relationships(s)
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1 Fos-ir was assessed after intra-pallidal injections of the excitatory amino acid agonist, NMDA, or the GABA(A) antagonist, bicuculline in normal rats and in those rendered Parkinsonian-like by lesioning dopaminergic neurons with the neurotoxin, 6-OHDA. Bicuculline Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus
2 Blocking tonically activated GABA(A) receptors with bicuculline (50 ng/0.5 microl) elevated Fos-ir in the VP to 423% above the contralateral, vehicle-injected side. Bicuculline Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus