Title : Calpain inhibition delays neutrophil apoptosis via cyclic AMP-independent activation of protein kinase A and protein kinase A-mediated stabilization of Mcl-1 and X-linked inhibitor of apoptosis (XIAP).

Pub. Date : 2008 Sep 15

PMID : 18647593






1 Functional Relationships(s)
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Protein Name
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1 Calpain inhibitors (PD150606 and N-acetyl-Leu-Leu-Nle-CHO) prevented spontaneous neutrophil apoptosis and degradation of Mcl-1 and XIAP, and the effects of calpain inhibitors on neutrophils were resistant to cycloheximide. n-acetyl-leu-leu-nle-cho MCL1 apoptosis regulator, BCL2 family member Homo sapiens