Pub. Date : 2008 Oct 1
PMID : 18645193
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Phase I clinical trial of a selective inhibitor of CYP17, abiraterone acetate, confirms that castration-resistant prostate cancer commonly remains hormone driven. | Abiraterone Acetate | cytochrome P450 family 17 subfamily A member 1 | Homo sapiens |
| 2 | To evaluate this, a trial of abiraterone acetate-a potent, selective, small-molecule inhibitor of cytochrome P (CYP) 17, a key enzyme in androgen synthesis-was pursued. | Abiraterone Acetate | cytochrome P450 family 17 subfamily A member 1 | Homo sapiens |
| 3 | Abiraterone acetate administration was associated with increased levels of adrenocorticotropic hormone and steroids upstream of CYP17 and with suppression of serum testosterone, downstream androgenic steroids, and estradiol in all patients. | Abiraterone Acetate | cytochrome P450 family 17 subfamily A member 1 | Homo sapiens |
| 4 | CONCLUSION: CYP17 blockade by abiraterone acetate is safe and has significant antitumor activity in CRPC. | Abiraterone Acetate | cytochrome P450 family 17 subfamily A member 1 | Homo sapiens |