Title : Effect of butylated hydroxytoluene, curcumin, propyl gallate and thiabendazole on cytochrome P450 forms in cultured human hepatocytes.

Pub. Date : 2008 Jun

PMID : 18570159






3 Functional Relationships(s)
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1 Effect of butylated hydroxytoluene, curcumin, propyl gallate and thiabendazole on cytochrome P450 forms in cultured human hepatocytes. Thiabendazole cytochrome P450 family 4 subfamily F member 3 Homo sapiens
2 The objective of this study was to investigate the effects of four food chemicals, namely butylated hydroxytoluene (BHT), curcumin (CC), propyl gallate (PG) and thiabendazole (TB), on cytochrome P450 (CYP) forms in cultured human hepatocytes. Thiabendazole cytochrome P450 family 4 subfamily F member 3 Homo sapiens
3 In summary, the results demonstrate that TB is a mixed inducer of CYP forms in human hepatocytes inducing CYP1A, CYP2B and CYP3A forms, whereas BHT is an inducer of CYP2B and CYP3A forms. Thiabendazole cytochrome P450 family 4 subfamily F member 3 Homo sapiens