Pub. Date : 2008 Jun
PMID : 18549623
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | This study was purposed to investigate the effects of bortezomib inducing cell apoptosis and influencing the erpression of Notch1 and NF-kappaB in MM RPMI 8226 cells. | Bortezomib | nuclear factor kappa B subunit 1 | Homo sapiens |
| 2 | The effect of bortezomib on apoptosis of MM RPMI8226 cells was assayed by transmission electron microscopy, flow cytometry and TUNEL; the expressions of Notch 1 and NF-kappaB in apoptotic RPMI8226 cells were detected by RT-PCR and immunofluorescence cytochemical staining respectively. | Bortezomib | nuclear factor kappa B subunit 1 | Homo sapiens |
| 3 | With the increase of bortezomib concentration, the typical apoptosis features of RPMI8226 cells were observed, the expressions of Notch1 and the expression of NF-kappaB decreased in nuclei and increased in cytoplasm. | Bortezomib | nuclear factor kappa B subunit 1 | Homo sapiens |
| 4 | It is concluded that Notch1 and NF-kappaB signaling pathways participate in bortezomib-inducing RPMI8226 cell apoptosis and there may be some correlation between the Notch 1 and NF-kappaB signaling pathways, indicating that Notch 1 signal may be a latent target in treating MM. | Bortezomib | nuclear factor kappa B subunit 1 | Homo sapiens |
| 5 | It is concluded that Notch1 and NF-kappaB signaling pathways participate in bortezomib-inducing RPMI8226 cell apoptosis and there may be some correlation between the Notch 1 and NF-kappaB signaling pathways, indicating that Notch 1 signal may be a latent target in treating MM. | Bortezomib | nuclear factor kappa B subunit 1 | Homo sapiens |