PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
18549623-6	2008	This study was purposed to investigate the effects of bortezomib inducing cell apoptosis and influencing the erpression of Notch1 and NF-kappaB in MM RPMI 8226 cells.	Bortezomib	54-64	nuclear factor kappa B subunit 1	Homo sapiens	134-143	
18549623-7	2008	The effect of bortezomib on apoptosis of MM RPMI8226 cells was assayed by transmission electron microscopy, flow cytometry and TUNEL; the expressions of Notch 1 and NF-kappaB in apoptotic RPMI8226 cells were detected by RT-PCR and immunofluorescence cytochemical staining respectively.	Bortezomib	14-24	nuclear factor kappa B subunit 1	Homo sapiens	165-174	
18549623-9	2008	With the increase of bortezomib concentration, the typical apoptosis features of RPMI8226 cells were observed, the expressions of Notch1 and the expression of NF-kappaB decreased in nuclei and increased in cytoplasm.	Bortezomib	21-31	nuclear factor kappa B subunit 1	Homo sapiens	159-168	
18549623-11	2008	It is concluded that Notch1 and NF-kappaB signaling pathways participate in bortezomib-inducing RPMI8226 cell apoptosis and there may be some correlation between the Notch 1 and NF-kappaB signaling pathways, indicating that Notch 1 signal may be a latent target in treating MM.	Bortezomib	76-86	nuclear factor kappa B subunit 1	Homo sapiens	32-41	
18549623-11	2008	It is concluded that Notch1 and NF-kappaB signaling pathways participate in bortezomib-inducing RPMI8226 cell apoptosis and there may be some correlation between the Notch 1 and NF-kappaB signaling pathways, indicating that Notch 1 signal may be a latent target in treating MM.	Bortezomib	76-86	nuclear factor kappa B subunit 1	Homo sapiens	178-187