Title : A functionally significant cross-talk between androgen receptor and ErbB2 pathways in estrogen receptor negative breast cancer.

Pub. Date : 2008 Jun

PMID : 18516291






2 Functional Relationships(s)
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1 Conversely, the growth stimulatory effect of heregulin can also be inhibited with flutamide, suggesting a cross-talk between the AR and ErbB2 pathways affecting cell proliferation. Flutamide erb-b2 receptor tyrosine kinase 2 Homo sapiens
2 Importantly, there is a synergy with the combined use of flutamide and AG825 on cell proliferation and apoptosis, which indicates a therapeutic advantage in the combined blockage of AR and ErbB2 pathways. Flutamide erb-b2 receptor tyrosine kinase 2 Homo sapiens