Pub. Date : 2009
PMID : 18515973
10 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | 7-Ketocholesterol upregulates interleukin-6 via mechanisms that are distinct from those of tumor necrosis factor-alpha, in vascular smooth muscle cells. | 7-ketocholesterol | interleukin 6 | Homo sapiens |
| 2 | This study investigated the effects of 7-ketocholesterol on interleukin (IL)-6 expression in vascular smooth muscle cells (VSMC). | 7-ketocholesterol | interleukin 6 | Homo sapiens |
| 3 | Among the 7 IL examined, only IL-6 transcript was increased by 7-ketocholesterol treatment in human aorta smooth muscle cells. | 7-ketocholesterol | interleukin 6 | Homo sapiens |
| 4 | IL-6 transcripts increased up to 24 h after treatment with 7-ketocholesterol, and this effect was profoundly repressed by treatment with p38 MAPK inhibitors and to a lesser extent JNK inhibitors. | 7-ketocholesterol | interleukin 6 | Homo sapiens |
| 5 | Mechanisms of IL-6 induction by 7-ketocholesterol were investigated in comparison with tumor necrosis factor (TNF)-alpha. | 7-ketocholesterol | interleukin 6 | Homo sapiens |
| 6 | 7-ketocholesterol significantly increased the amount of intracellular IL-6 protein in the presence of brefeldin A. | 7-ketocholesterol | interleukin 6 | Homo sapiens |
| 7 | 7-Ketocholesterol also enhanced IL-6 release from VSMC. | 7-ketocholesterol | interleukin 6 | Homo sapiens |
| 8 | IL-6 release by 7-ketocholesterol, although significant, was not as remarkable as that induced by TNF-alpha. | 7-ketocholesterol | interleukin 6 | Homo sapiens |
| 9 | These data suggest that 7-ketocholesterol upregulates IL-6 via mechanisms distinct from TNF-alpha and contributes to the intra- and extracellular IL-6 deposits within the vasculature. | 7-ketocholesterol | interleukin 6 | Homo sapiens |
| 10 | These data suggest that 7-ketocholesterol upregulates IL-6 via mechanisms distinct from TNF-alpha and contributes to the intra- and extracellular IL-6 deposits within the vasculature. | 7-ketocholesterol | interleukin 6 | Homo sapiens |