PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
18515973-0	2009	7-Ketocholesterol upregulates interleukin-6 via mechanisms that are distinct from those of tumor necrosis factor-alpha, in vascular smooth muscle cells.	7-ketocholesterol	0-17	interleukin 6	Homo sapiens	30-43	
18515973-1	2009	This study investigated the effects of 7-ketocholesterol on interleukin (IL)-6 expression in vascular smooth muscle cells (VSMC).	7-ketocholesterol	39-56	interleukin 6	Homo sapiens	60-78	
18515973-2	2009	Among the 7 IL examined, only IL-6 transcript was increased by 7-ketocholesterol treatment in human aorta smooth muscle cells.	7-ketocholesterol	63-80	interleukin 6	Homo sapiens	30-34	
18515973-3	2009	IL-6 transcripts increased up to 24 h after treatment with 7-ketocholesterol, and this effect was profoundly repressed by treatment with p38 MAPK inhibitors and to a lesser extent JNK inhibitors.	7-ketocholesterol	59-76	interleukin 6	Homo sapiens	0-4	
18515973-5	2009	Mechanisms of IL-6 induction by 7-ketocholesterol were investigated in comparison with tumor necrosis factor (TNF)-alpha.	7-ketocholesterol	32-49	interleukin 6	Homo sapiens	14-18	
18515973-8	2009	7-ketocholesterol significantly increased the amount of intracellular IL-6 protein in the presence of brefeldin A.	7-ketocholesterol	0-17	interleukin 6	Homo sapiens	70-74	
18515973-9	2009	7-Ketocholesterol also enhanced IL-6 release from VSMC.	7-ketocholesterol	0-17	interleukin 6	Homo sapiens	32-36	
18515973-10	2009	IL-6 release by 7-ketocholesterol, although significant, was not as remarkable as that induced by TNF-alpha.	7-ketocholesterol	16-33	interleukin 6	Homo sapiens	0-4	
18515973-11	2009	These data suggest that 7-ketocholesterol upregulates IL-6 via mechanisms distinct from TNF-alpha and contributes to the intra- and extracellular IL-6 deposits within the vasculature.	7-ketocholesterol	24-41	interleukin 6	Homo sapiens	54-58	
18515973-11	2009	These data suggest that 7-ketocholesterol upregulates IL-6 via mechanisms distinct from TNF-alpha and contributes to the intra- and extracellular IL-6 deposits within the vasculature.	7-ketocholesterol	24-41	interleukin 6	Homo sapiens	146-150