Pub. Date : 2008 May
PMID : 18420860
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | BACKGROUND: Animal models show us that specific activation of the p38 mitogen-activated protein kinase (MAPK) may be a pivotal step in lidocaine neurotoxicity, but this has not been investigated in the case of two very widely used local anesthetics, bupivacaine and ropivacaine. | Bupivacaine | mitogen-activated protein kinase 14 | Homo sapiens |
| 2 | Finally, the relevance of MAPK pathways in bupivacaine- and ropivacaine-induced neurotoxicity was determined by selectively inhibiting activity of p38 MAPK, JNK, and ERK. | Bupivacaine | mitogen-activated protein kinase 14 | Homo sapiens |
| 3 | Specifically, we demonstrated the relevance of both p38 MAPK and JNK pathways for the neurotoxicity of bupivacaine and characterized the involvement of the p38 MAPK pathway in the neurotoxicity of ropivacaine. | Bupivacaine | mitogen-activated protein kinase 14 | Homo sapiens |