PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
18420860-1	2008	BACKGROUND: Animal models show us that specific activation of the p38 mitogen-activated protein kinase (MAPK) may be a pivotal step in lidocaine neurotoxicity, but this has not been investigated in the case of two very widely used local anesthetics, bupivacaine and ropivacaine.	Bupivacaine	250-261	mitogen-activated protein kinase 14	Homo sapiens	66-102	
18420860-6	2008	Finally, the relevance of MAPK pathways in bupivacaine- and ropivacaine-induced neurotoxicity was determined by selectively inhibiting activity of p38 MAPK, JNK, and ERK.	Bupivacaine	43-54	mitogen-activated protein kinase 14	Homo sapiens	147-150	
18420860-9	2008	Specifically, we demonstrated the relevance of both p38 MAPK and JNK pathways for the neurotoxicity of bupivacaine and characterized the involvement of the p38 MAPK pathway in the neurotoxicity of ropivacaine.	Bupivacaine	103-114	mitogen-activated protein kinase 14	Homo sapiens	52-55