Title : Dexamethasone-induced expression of endothelial mitogen-activated protein kinase phosphatase-1 involves activation of the transcription factors activator protein-1 and 3',5'-cyclic adenosine 5'-monophosphate response element-binding protein and the generation of reactive oxygen species.

Pub. Date : 2008 Jul

PMID : 18403484






4 Functional Relationships(s)
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1 Using Western blot analysis, we found that dexamethasone rapidly activates ERK, c-jun N-terminal kinase (JNK), and p38 MAPK in human umbilical vein endothelial cells. Dexamethasone mitogen-activated protein kinase 8 Homo sapiens
2 Using Western blot analysis, we found that dexamethasone rapidly activates ERK, c-jun N-terminal kinase (JNK), and p38 MAPK in human umbilical vein endothelial cells. Dexamethasone mitogen-activated protein kinase 8 Homo sapiens
3 Using EMSA and a decoy oligonucleotide approach, the transcription factors activator protein-1 (activated by ERK and JNK) and cAMP response element-binding protein (activated by ERK) were found to be involved in the up-regulation of MKP-1 by dexamethasone. Dexamethasone mitogen-activated protein kinase 8 Homo sapiens
4 Interestingly, dexamethasone induces the generation of reactive oxygen species (measured by dihydrofluorescein assay), which participate in the signaling process by triggering JNK activation. Dexamethasone mitogen-activated protein kinase 8 Homo sapiens