Pub. Date : 2008 Apr
PMID : 18294632
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Chronic administration of morphine is associated with a decrease in surface AMPA GluR1 receptor subunit in dopamine D1 receptor expressing neurons in the shell and non-D1 receptor expressing neurons in the core of the rat nucleus accumbens. | Morphine | glutamate ionotropic receptor AMPA type subunit 1 | Rattus norvegicus |
| 2 | Immunogold electron microscopy was used to quantify the surface expression of the AMPA GluR1 subunit in dendritic profiles of neurons in the Acb in response to intermittent 14-day non-contingent injections of escalating doses of morphine, a model that parallels opioid self-administration. | Morphine | glutamate ionotropic receptor AMPA type subunit 1 | Rattus norvegicus |
| 3 | We provide the first report that chronic morphine administration is associated with a receptor-phenotypic decrease in surface trafficking of GluR1 in Acb subregions. | Morphine | glutamate ionotropic receptor AMPA type subunit 1 | Rattus norvegicus |
| 4 | When compared to saline injected animals, morphine produced a decrease in plasma membrane GluR1 labeling in medium- and large-sized D1R expressing dendritic profiles in the Acb shell. | Morphine | glutamate ionotropic receptor AMPA type subunit 1 | Rattus norvegicus |
| 5 | These results indicate that chronic intermittent injection of escalating doses of morphine is accompanied by ultrastructural plasticity of GluR1 in neurons that are responsive to glutamate and dopamine-induced D1R activation in the Acb shell, and neurons capable of responding to glutamate but not D1R receptor stimulation in the Acb core. | Morphine | glutamate ionotropic receptor AMPA type subunit 1 | Rattus norvegicus |