Title : Sulforaphane inhibition of monocyte adhesion via the suppression of ICAM-1 and NF-kappaB is dependent upon glutathione depletion in endothelial cells.

Pub. Date : 2008 Jan

PMID : 18248854






2 Functional Relationships(s)
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1 The intracellular GSH levels in SFN-treated ECs were observed to be reduced, the time course coincident with the suppression of P65 translocation and IkappaB-alpha degradation. sulforaphane RELA proto-oncogene, NF-kB subunit Homo sapiens
2 NAC and GSH reverse the inhibitory effects of SFN upon p65 translocation and IkappaB-alpha degradation when preincubated with this agent. sulforaphane RELA proto-oncogene, NF-kB subunit Homo sapiens