Title : Phosphorylation of c-Abl by protein kinase Pak2 regulates differential binding of ABI2 and CRK.

Pub. Date : 2008 Jan 22

PMID : 18161990






4 Functional Relationships(s)
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1 The interaction of c-Abl with the Abl interactor protein Abi2 is shown to be negatively regulated by phosphorylation of serines 637 and 638. Serine ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens
2 The interaction of c-Abl with the Abl interactor protein Abi2 is shown to be negatively regulated by phosphorylation of serines 637 and 638. Serine ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens
3 Mutation of serines 637-639 to alanine (3A) or aspartate (3D) results in an increased tyrosine kinase activity of c-Abl 3D, and a slight reduction of the activity of the 3A mutant, as compared to wild-type (WT) c-Abl. Serine ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens
4 Mutation of serines 637-639 to alanine (3A) or aspartate (3D) results in an increased tyrosine kinase activity of c-Abl 3D, and a slight reduction of the activity of the 3A mutant, as compared to wild-type (WT) c-Abl. Serine ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens