Title : Identification of cytochrome P450 enzymes responsible for N -dealkylation of a new oral erectogenic, mirodenafil.

Pub. Date : 2008 Jan

PMID : 18098061






3 Functional Relationships(s)
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1 CYP3A4 was identified as the major enzyme and CYP2C8 as a minor enzyme responsible for mirodenafil N-dealkylation based on correlation analysis, inhibition studies, and cDNA-expressed CYP enzyme activities. mirodenafil cytochrome P450 family 3 subfamily A member 4 Homo sapiens
2 Plasma concentrations of mirodenafil and its N-dealkylated metabolite could therefore change with co-administration of known CYP3A4 inducers or inhibitors. mirodenafil cytochrome P450 family 3 subfamily A member 4 Homo sapiens
3 Mirodenafil inhibited CYP3A4, CYP2C19 and CYP2D6 activities with IC50 values of 15.6, 38.2 and 77.0 microM, respectively, in human liver microsomes. mirodenafil cytochrome P450 family 3 subfamily A member 4 Homo sapiens