PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
18098061-2	2008	CYP3A4 was identified as the major enzyme and CYP2C8 as a minor enzyme responsible for mirodenafil N-dealkylation based on correlation analysis, inhibition studies, and cDNA-expressed CYP enzyme activities.	mirodenafil	87-98	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	0-6	
18098061-3	2008	Plasma concentrations of mirodenafil and its N-dealkylated metabolite could therefore change with co-administration of known CYP3A4 inducers or inhibitors.	mirodenafil	25-36	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	125-131	
18098061-4	2008	Mirodenafil inhibited CYP3A4, CYP2C19 and CYP2D6 activities with IC50 values of 15.6, 38.2 and 77.0 microM, respectively, in human liver microsomes.	mirodenafil	0-11	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	22-28