Title : Cholesterol retention in Alzheimer's brain is responsible for high beta- and gamma-secretase activities and Abeta production.

Pub. Date : 2008 Mar

PMID : 18086530






2 Functional Relationships(s)
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1 Treatment of N2a cells with LXR, RXR or PPAR agonists strongly stimulated cellular cholesterol efflux to HDL and reduced cellular cholesterol and beta-/gamma-secretase activities. Cholesterol peroxisome proliferator activated receptor alpha Mus musculus
2 Treatment of N2a cells with LXR, RXR or PPAR agonists strongly stimulated cellular cholesterol efflux to HDL and reduced cellular cholesterol and beta-/gamma-secretase activities. Cholesterol peroxisome proliferator activated receptor alpha Mus musculus