Pub. Date : 2008 Feb 12
PMID : 18082731
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | LPS-induced NO production and inducible NO synthase (iNOS) expression were significantly enhanced in the macrophages isolated from rats injected intraperitoneally with docetaxel (4 mg/kg body weight per day for 5 consecutive days) compared with those in macrophages from control rats administrated a vehicle. | Docetaxel | nitric oxide synthase 2 | Rattus norvegicus |
| 2 | LPS-induced NO production and inducible NO synthase (iNOS) expression were significantly enhanced in the macrophages isolated from rats injected intraperitoneally with docetaxel (4 mg/kg body weight per day for 5 consecutive days) compared with those in macrophages from control rats administrated a vehicle. | Docetaxel | nitric oxide synthase 2 | Rattus norvegicus |
| 3 | On the other hand, in vitro treatment of macrophages with docetaxel (5 and 10 microg/ml) inhibited LPS-induced NO production and iNOS expression. | Docetaxel | nitric oxide synthase 2 | Rattus norvegicus |
| 4 | These results suggest that docetaxel has an enhancing action in vivo on LPS-induced iNOS expression and subsequent NO production through stimulation of p38 activity in alveolar macrophages. | Docetaxel | nitric oxide synthase 2 | Rattus norvegicus |