Pub. Date : 2008 Feb
PMID : 18063707
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Modulation of ileal bile acid transporter (ASBT) activity by depletion of plasma membrane cholesterol: association with lipid rafts. | Cholesterol | solute carrier family 10 member 2 | Homo sapiens |
| 2 | To gain insight into the cellular regulation of ASBT, we investigated the association of ASBT with cholesterol and sphingolipid-enriched specialized plasma membrane microdomains known as lipid rafts and examined the role of membrane cholesterol in maintaining ASBT function. | Cholesterol | solute carrier family 10 member 2 | Homo sapiens |
| 3 | To gain insight into the cellular regulation of ASBT, we investigated the association of ASBT with cholesterol and sphingolipid-enriched specialized plasma membrane microdomains known as lipid rafts and examined the role of membrane cholesterol in maintaining ASBT function. | Cholesterol | solute carrier family 10 member 2 | Homo sapiens |
| 4 | Disruption of lipid rafts by depletion of membrane cholesterol with methyl-beta-cyclodextrin (MbetaCD) significantly reduced the association of ASBT with lipid rafts, which was paralleled by a decrease in ASBT activity in Caco-2 and HEK-293 cells treated with MbetaCD. | Cholesterol | solute carrier family 10 member 2 | Homo sapiens |
| 5 | Our study illustrates that cholesterol content of lipid rafts is essential for the optimal activity of ASBT and support the association of ASBT with lipid rafts. | Cholesterol | solute carrier family 10 member 2 | Homo sapiens |
| 6 | Our study illustrates that cholesterol content of lipid rafts is essential for the optimal activity of ASBT and support the association of ASBT with lipid rafts. | Cholesterol | solute carrier family 10 member 2 | Homo sapiens |
| 7 | These findings suggest a novel mechanism by which ASBT activity may be rapidly modulated by alterations in cholesterol content of plasma membrane and thus have important implications in processes related to maintenance of bile acid and cholesterol homeostasis. | Cholesterol | solute carrier family 10 member 2 | Homo sapiens |
| 8 | These findings suggest a novel mechanism by which ASBT activity may be rapidly modulated by alterations in cholesterol content of plasma membrane and thus have important implications in processes related to maintenance of bile acid and cholesterol homeostasis. | Cholesterol | solute carrier family 10 member 2 | Homo sapiens |