Title : Repeated treatment with haloperidol, but not olanzapine, alters synaptic NMDA receptor composition in rat striatum.

Pub. Date : 2008 Jul

PMID : 18061412






1 Functional Relationships(s)
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1 We here show that repeated administration of the first generation antipsychotic haloperidol, but not of the second generation olanzapine, significantly reduced the expression of NMDA subunit NR2A at striatal synapses, whereas both drugs decreased alphaCaMKII protein levels and autophosphorylation degree. N-Methylaspartate glutamate ionotropic receptor NMDA type subunit 2A Rattus norvegicus