| Protein Name | glutamate ionotropic receptor NMDA type subunit 2A |
|---|---|
| Organism | Rattus norvegicus |
| Gene ID | 24409 |
| Gene Symbol | Grin2a |
| UniProt | Q00959 (NMDE1_RAT) |
| Relationships |
Total Number of functionally related compound(s) :
261
Total Number of Articles : 407 |
Description |
glutamate ionotropic receptor NMDA type subunit 2A |
| Gene Summary |
Enables several functions, including enzyme binding activity; glutamate binding activity; and monoatomic ion channel activity. Contributes to extracellularly glutamate-gated ion channel activity and monoatomic cation channel activity. Involved in several processes, including modulation of chemical synaptic transmission; nervous system development; and regulation of signal transduction. Located in several cellular components, including dendrite; postsynaptic density, intracellular component; and postsynaptic membrane. Part of NMDA selective glutamate receptor complex. Is active in glutamatergic synapse; parallel fiber to Purkinje cell synapse; and presynaptic membrane. Used to study hyperhomocysteinemia and transient cerebral ischemia. Biomarker of cognitive disorder; placental insufficiency; post-traumatic stress disorder; status epilepticus; and withdrawal disorder. Human ortholog(s) of this gene implicated in several diseases, including Huntington's disease; alcohol dependence; bipolar disorder; colorectal cancer; and heroin dependence. Orthologous to human GRIN2A (glutamate ionotropic receptor NMDA type subunit 2A). [provided by Alliance of Genome Resources, Jul 2025] |
| synonyms |
|
| Properties | |