Title : Genetic deletion of low density lipoprotein receptor impairs sterol-induced mouse macrophage ABCA1 expression. A new SREBP1-dependent mechanism.

Pub. Date : 2008 Jan 25

PMID : 18029360






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Cholesterol or oxysterols induced ABCA1 expression in wild type macrophages but had little or inhibitory effects on ABCA1 expression in LDLR(-/-) macrophages. Oxysterols ATP-binding cassette, sub-family A (ABC1), member 1 Mus musculus
2 Oxysterol synergized with nonsteroid LXR ligand induced ABCA1 expression in wild type macrophages but blocked induction in LDLR(-/-) cells. Oxysterols ATP-binding cassette, sub-family A (ABC1), member 1 Mus musculus