| Protein Name | ATP-binding cassette, sub-family A member 1 |
|---|---|
| Organism | Mus musculus |
| Gene ID | 11303 |
| Gene Symbol | Abca1 |
| UniProt | P41233 (ABCA1_MOUSE), Q8BPY1 (Q8BPY1_MOUSE) |
| Relationships |
Total Number of functionally related compound(s) :
321
Total Number of Articles : 672 |
Description |
ATP-binding cassette, sub-family A member 1 |
| Gene Summary |
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. In humans, this protein functions as a cholesterol efflux pump in the cellular lipid removal pathway. Mutations in the human gene have been associated with Tangier's disease and familial high-density lipoprotein deficiency. [provided by RefSeq, Jul 2008] |
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