Pub. Date : 2007 Jul 20
PMID : 17634479
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Quantitative measurement of epidermal growth factor receptor is a negative predictive factor for tamoxifen response in hormone receptor positive premenopausal breast cancer. | Tamoxifen | epidermal growth factor receptor | Homo sapiens |
| 2 | Here we assess the relationship between EGFR expression and tamoxifen response, with a new quantitative technology. | Tamoxifen | epidermal growth factor receptor | Homo sapiens |
| 3 | RESULTS: In ER-positive patients, tamoxifen-treated patients with low EGFR expression (n = 113) showed a significant effect by 2 years of adjuvant tamoxifen (P = .01), in contrast to no treatment effect in the EGFR-high group (n = 73, P = .69). | Tamoxifen | epidermal growth factor receptor | Homo sapiens |
| 4 | RESULTS: In ER-positive patients, tamoxifen-treated patients with low EGFR expression (n = 113) showed a significant effect by 2 years of adjuvant tamoxifen (P = .01), in contrast to no treatment effect in the EGFR-high group (n = 73, P = .69). | Tamoxifen | epidermal growth factor receptor | Homo sapiens |
| 5 | RESULTS: In ER-positive patients, tamoxifen-treated patients with low EGFR expression (n = 113) showed a significant effect by 2 years of adjuvant tamoxifen (P = .01), in contrast to no treatment effect in the EGFR-high group (n = 73, P = .69). | Tamoxifen | epidermal growth factor receptor | Homo sapiens |
| 6 | A significant beneficial effect of tamoxifen treatment was seen in the EGFR-low group (hazard ratio [HR] = 0.43 (95% CI, 0.22 to 0.84; P = .013) in contrast to no effect in the EGFR-high group (HR = 1.14; 95% CI, 0.59 to 2.22; P = .7) by using a Cox model. | Tamoxifen | epidermal growth factor receptor | Homo sapiens |
| 7 | A significant beneficial effect of tamoxifen treatment was seen in the EGFR-low group (hazard ratio [HR] = 0.43 (95% CI, 0.22 to 0.84; P = .013) in contrast to no effect in the EGFR-high group (HR = 1.14; 95% CI, 0.59 to 2.22; P = .7) by using a Cox model. | Tamoxifen | epidermal growth factor receptor | Homo sapiens |
| 8 | CONCLUSION: This study provides clinical evidence that confirms the basic work that has shown high EGFR can indicate resistance to tamoxifen. | Tamoxifen | epidermal growth factor receptor | Homo sapiens |