PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 17634479-0 2007 Quantitative measurement of epidermal growth factor receptor is a negative predictive factor for tamoxifen response in hormone receptor positive premenopausal breast cancer. Tamoxifen 97-106 epidermal growth factor receptor Homo sapiens 28-60 17634479-2 2007 Here we assess the relationship between EGFR expression and tamoxifen response, with a new quantitative technology. Tamoxifen 60-69 epidermal growth factor receptor Homo sapiens 40-44 17634479-5 2007 RESULTS: In ER-positive patients, tamoxifen-treated patients with low EGFR expression (n = 113) showed a significant effect by 2 years of adjuvant tamoxifen (P = .01), in contrast to no treatment effect in the EGFR-high group (n = 73, P = .69). Tamoxifen 34-43 epidermal growth factor receptor Homo sapiens 70-74 17634479-5 2007 RESULTS: In ER-positive patients, tamoxifen-treated patients with low EGFR expression (n = 113) showed a significant effect by 2 years of adjuvant tamoxifen (P = .01), in contrast to no treatment effect in the EGFR-high group (n = 73, P = .69). Tamoxifen 34-43 epidermal growth factor receptor Homo sapiens 210-214 17634479-5 2007 RESULTS: In ER-positive patients, tamoxifen-treated patients with low EGFR expression (n = 113) showed a significant effect by 2 years of adjuvant tamoxifen (P = .01), in contrast to no treatment effect in the EGFR-high group (n = 73, P = .69). Tamoxifen 147-156 epidermal growth factor receptor Homo sapiens 70-74 17634479-7 2007 A significant beneficial effect of tamoxifen treatment was seen in the EGFR-low group (hazard ratio [HR] = 0.43 (95% CI, 0.22 to 0.84; P = .013) in contrast to no effect in the EGFR-high group (HR = 1.14; 95% CI, 0.59 to 2.22; P = .7) by using a Cox model. Tamoxifen 35-44 epidermal growth factor receptor Homo sapiens 71-75 17634479-7 2007 A significant beneficial effect of tamoxifen treatment was seen in the EGFR-low group (hazard ratio [HR] = 0.43 (95% CI, 0.22 to 0.84; P = .013) in contrast to no effect in the EGFR-high group (HR = 1.14; 95% CI, 0.59 to 2.22; P = .7) by using a Cox model. Tamoxifen 35-44 epidermal growth factor receptor Homo sapiens 177-181 17634479-8 2007 CONCLUSION: This study provides clinical evidence that confirms the basic work that has shown high EGFR can indicate resistance to tamoxifen. Tamoxifen 131-140 epidermal growth factor receptor Homo sapiens 99-103