Title : [Mitochondrial transmembrane potential loss caused by reactive oxygen species plays a major role in sodium selenite-induced apoptosis in NB4 cells].

Pub. Date : 2007 Jun

PMID : 17633456






3 Functional Relationships(s)
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1 Sodium selenite also downregulated Bcl-xl and activated Bax and Bid at protein level. Sodium Selenite BH3 interacting domain death agonist Homo sapiens
2 Pretreatment with antioxidant MnTmPy almost fully abrogated the proapoptotic effect of sodium selenite prevented the cleavage of Bid protein and in turn the mitochondrail transmembrane potential loss. Sodium Selenite BH3 interacting domain death agonist Homo sapiens
3 CONCLUSIONS: Sodium selenite may induce apoptosis by inducing ROS production in NB4 cells, which leads to the downregulation of Bcl-xl, upregulation of Bax, and cleavage and activation of Bid. Sodium Selenite BH3 interacting domain death agonist Homo sapiens