Title : The DNA-binding epidermal growth factor-receptor inhibitor PD153035 and other DNA-intercalating cytotoxic drugs reactivate the expression of the retinoic acid receptor-beta tumor-suppressor gene in breast cancer cells.

Pub. Date : 2007 Nov

PMID : 17608728






1 Functional Relationships(s)
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1 We have previously shown that the epidermal growth factor-receptor (EGFR) tyrosine kinase inhibitor PD153035 induces retinoic acid receptor-beta (RAR-beta) expression in malignant cells by mechanisms that are independent of its blocking activity on EGFR (ErbB1) or on any other ErbB receptor (ErbB2, ErbB3, ErbB4). 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline erb-b2 receptor tyrosine kinase 2 Homo sapiens