Title : In vitro assessment of cytochrome P450 inhibition: strategies for increasing LC/MS-based assay throughput using a one-point IC(50) method and multiplexing high-performance liquid chromatography.

Pub. Date : 2007 Sep

PMID : 17542019






1 Functional Relationships(s)
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1 Probe substrates were phenacetin, diclofenac, S-mephenytoin, and dextromethorphan for CYP1A2, CYP2C9, CYP2C19, and CYP2D6, respectively. Dextromethorphan cytochrome P450 family 2 subfamily C member 9 Homo sapiens