Title : Heat shock protein 27 protects L929 cells from cisplatin-induced apoptosis by enhancing Akt activation and abating suppression of thioredoxin reductase activity.

Pub. Date : 2007 May 15

PMID : 17504983






4 Functional Relationships(s)
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1 It is attempted to know how Hsp27 endues cell with cisplatin resistance by interfering with upstream of both apoptosis signal-regulating kinase 1 (ASK1)/p38 mitogen-activated protein kinase-activated apoptotic signaling and serine/threonine kinase Akt-dependent survival signaling. Cisplatin mitogen-activated protein kinase 14 Homo sapiens
2 The cisplatin-induced apoptosis and activation of ASK1, p38, and Akt were compared in control cells, cells overexpressing Hsp27, and cells with their endogenous Hsp27 knocked down. Cisplatin mitogen-activated protein kinase 14 Homo sapiens
3 The p38 inhibitors obviously decreased whereas Akt inhibitors markedly increased the apoptotic fraction in cisplatin-treated cells. Cisplatin mitogen-activated protein kinase 14 Homo sapiens
4 CONCLUSIONS: Hsp27 endues cells with cisplatin resistance via depression of the drug-induced ASK1/p38 activation and enhancement of the drug-induced Akt activation. Cisplatin mitogen-activated protein kinase 14 Homo sapiens