Pub. Date : 2007 Jul
PMID : 17495969
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Here, we investigated the potential synergy of bortezomib and ATO on Bcr-Abl(+) leukemic K562 cells. | Arsenic Trioxide | ABL proto-oncogene 1, non-receptor tyrosine kinase | Homo sapiens |
| 2 | The results showed that cotreatment of bortezomib at 32 nM, a half concentration for growth arrest, and ATO at 1 microM, a dose with no significant cytotoxic effect, synergistically induced apoptosis in the cell line, followed by enhanced mitochondrial dysfunction, release of cytochrome c and apoptosis-inducing factor, caspase-3 cleavage and degradation of poly-adenosine diphosphate-ribose polymerase together with the decreased Bcr-Abl protein. | Arsenic Trioxide | ABL proto-oncogene 1, non-receptor tyrosine kinase | Homo sapiens |