PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 17495969-3 2007 Here, we investigated the potential synergy of bortezomib and ATO on Bcr-Abl(+) leukemic K562 cells. Arsenic Trioxide 62-65 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 69-76 17495969-4 2007 The results showed that cotreatment of bortezomib at 32 nM, a half concentration for growth arrest, and ATO at 1 microM, a dose with no significant cytotoxic effect, synergistically induced apoptosis in the cell line, followed by enhanced mitochondrial dysfunction, release of cytochrome c and apoptosis-inducing factor, caspase-3 cleavage and degradation of poly-adenosine diphosphate-ribose polymerase together with the decreased Bcr-Abl protein. Arsenic Trioxide 104-107 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 432-439