Pub. Date : 2007 Aug
PMID : 17389610
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Targeting human 8-oxoguanine DNA glycosylase (hOGG1) to mitochondria enhances cisplatin cytotoxicity in hepatoma cells. | Cisplatin | 8-oxoguanine DNA glycosylase | Homo sapiens |
| 2 | Targeting human 8-oxoguanine DNA glycosylase (hOGG1) to mitochondria enhances cisplatin cytotoxicity in hepatoma cells. | Cisplatin | 8-oxoguanine DNA glycosylase | Homo sapiens |
| 3 | Following exposure to a commonly used chemotherapeutic agent, cisplatin, cancer cells over-expressing hOGG1 displayed much shortened long-term survival when compared with control cells. | Cisplatin | 8-oxoguanine DNA glycosylase | Homo sapiens |
| 4 | Our results suggest that over-expression of hOGG1 in mitochondria may promote mitochondrial DNA damage by creating an imbalance in the BER pathway and sensitize cancer cells to cisplatin. | Cisplatin | 8-oxoguanine DNA glycosylase | Homo sapiens |