| Protein Name | 8-oxoguanine DNA glycosylase |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 4968 |
| Gene Symbol | OGG1 |
| UniProt | O15527 (OGG1_HUMAN), E5KPN0 (E5KPN0_HUMAN), E5KPN1 (E5KPN1_HUMAN), E5KPM5 (E5KPM5_HUMAN), E5KPM7 (E5KPM7_HUMAN), E5KPM9 (E5KPM9_HUMAN), E5KPM8 (E5KPM8_HUMAN), E5KPM6 (E5KPM6_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
416
Total Number of Articles : 731 |
Description |
8-oxoguanine DNA glycosylase |
| Gene Summary |
This gene encodes the enzyme responsible for the excision of 8-oxoguanine, a mutagenic base byproduct which occurs as a result of exposure to reactive oxygen. The action of this enzyme includes lyase activity for chain cleavage. Alternative splicing of the C-terminal region of this gene classifies splice variants into two major groups, type 1 and type 2, depending on the last exon of the sequence. Type 1 alternative splice variants end with exon 7 and type 2 end with exon 8. All variants share the N-terminal region in common, which contains a mitochondrial targeting signal that is essential for mitochondrial localization. Many alternative splice variants for this gene have been described, but the full-length nature for every variant has not been determined. [provided by RefSeq, Aug 2008] |
| synonyms |
|
| Properties | |