Title : The role of ascorbate in the modulation of HIF-1alpha protein and HIF-dependent transcription by chromium(VI) and nickel(II).

Pub. Date : 2007 Apr 15

PMID : 17382205






3 Functional Relationships(s)
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1 Here we investigated the induction of HIF-1 by another metal, chromium, which cannot replace iron in the enzyme. Chromium hypoxia inducible factor 1 subunit alpha Homo sapiens
2 In agreement with these data chromium(VI) stabilizes HIF-1alpha protein in cells only until it is reduced to chromium(III). Chromium hypoxia inducible factor 1 subunit alpha Homo sapiens
3 However, repeated (chronic) exposure to chromium(VI) can also lead to extended stabilization of HIF-1alpha. Chromium hypoxia inducible factor 1 subunit alpha Homo sapiens