Title : Targeting homeostatic mechanisms of endoplasmic reticulum stress to increase susceptibility of cancer cells to fenretinide-induced apoptosis: the role of stress proteins ERdj5 and ERp57.

Pub. Date : 2007 Apr 10

PMID : 17353921






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 The ER stress genes ERdj5, ERp57, GRP78, calreticulin and calnexin were induced in neuroectodermal tumour cells by fenretinide. Fenretinide protein disulfide isomerase family A member 3 Homo sapiens
2 Knockdown of ERp57 or ERdj5 by RNA interference in these cells increased the apoptotic response to fenretinide. Fenretinide protein disulfide isomerase family A member 3 Homo sapiens