Protein Name protein disulfide isomerase family A member 3
Organism Homo sapiens
Gene ID 2923
Gene Symbol


UniProt P30101 (PDIA3_HUMAN), V9HVY3 (V9HVY3_HUMAN)
Relationships Total Number of functionally related compound(s) : 158
Total Number of Articles : 196

protein disulfide isomerase family A member 3

Gene Summary

This gene encodes a protein of the endoplasmic reticulum that interacts with lectin chaperones calreticulin and calnexin to modulate folding of newly synthesized glycoproteins. The protein was once thought to be a phospholipase; however, it has been demonstrated that the protein actually has protein disulfide isomerase activity. It is thought that complexes of lectins and this protein mediate protein folding by promoting formation of disulfide bonds in their glycoprotein substrates. This protein also functions as a molecular chaperone that prevents the formation of protein aggregates. [provided by RefSeq, Dec 2016]

  • protein disulfide-isomerase A3
  • 58 kDa glucose-regulated protein
  • 58 kDa microsomal protein
Click to show/hide the synonyms