Pub. Date : 2007 Mar 1
PMID : 17332297
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Pharmacokinetic analysis at 1.3 mg/m(2) revealed a clearance of 11 mL/h/m(2), a central volume of distribution of 6.7 L/m(2), and a terminal half-life of 12.6 h. NF-kappaB activity was examined in five patients and was noted to transiently increase and then decrease 4- to 6-fold by 24 h following bortezomib in two patients. | Bortezomib | nuclear factor kappa B subunit 1 | Homo sapiens |
| 2 | Although bortezomib treatment inhibited NF-kappaB activity, bortezomib had little activity as a single agent in this population. | Bortezomib | nuclear factor kappa B subunit 1 | Homo sapiens |