Title : Identification of a novel intestinal first pass metabolic pathway: NQO1 mediated quinone reduction and subsequent glucuronidation.

Pub. Date : 2007 Feb

PMID : 17305492






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Dicoumarol, a specific inhibitor of the NAD(P)H dependent quinone oxidoreductase (NQO1), significantly inhibited the metabolic elimination of TS in a noncompetitive way, suggesting that NQO1 was responsible for the quinone reduction of TS to form the catechol intermediate. catechol NAD(P)H quinone dehydrogenase 1 Rattus norvegicus
2 Dicoumarol, a specific inhibitor of the NAD(P)H dependent quinone oxidoreductase (NQO1), significantly inhibited the metabolic elimination of TS in a noncompetitive way, suggesting that NQO1 was responsible for the quinone reduction of TS to form the catechol intermediate. catechol NAD(P)H quinone dehydrogenase 1 Rattus norvegicus