Pub. Date : 2007 Mar
PMID : 17268847
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Treatment of H19-7 cells with bFGF increased NO production through upregulated iNOS/ nNOS expression, and also increased expressions of neuronal markers such as brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT3) and Neuro-D. Pretreatment of the cells with nicotine decreased iNOS promoter activity as well as iNOS/nNOS expression induced by bFGF, resulting in decreased NO production. | Nicotine | fibroblast growth factor 2 | Rattus norvegicus |
| 2 | Nicotine inhibits bFGF-induced neurite outgrowth through suppression of NO synthesis in H19-7 cells. | Nicotine | fibroblast growth factor 2 | Rattus norvegicus |
| 3 | In this study, we elucidated how nicotine inhibits neuronal differentiation induced by the basic fibroblast growth factor (bFGF) in hippocampal cell line, H19-7 cells, because nicotine is one of the key neuroregulatory components. | Nicotine | fibroblast growth factor 2 | Rattus norvegicus |
| 4 | In this study, we elucidated how nicotine inhibits neuronal differentiation induced by the basic fibroblast growth factor (bFGF) in hippocampal cell line, H19-7 cells, because nicotine is one of the key neuroregulatory components. | Nicotine | fibroblast growth factor 2 | Rattus norvegicus |
| 5 | In this study, we elucidated how nicotine inhibits neuronal differentiation induced by the basic fibroblast growth factor (bFGF) in hippocampal cell line, H19-7 cells, because nicotine is one of the key neuroregulatory components. | Nicotine | fibroblast growth factor 2 | Rattus norvegicus |
| 6 | In this study, we elucidated how nicotine inhibits neuronal differentiation induced by the basic fibroblast growth factor (bFGF) in hippocampal cell line, H19-7 cells, because nicotine is one of the key neuroregulatory components. | Nicotine | fibroblast growth factor 2 | Rattus norvegicus |
| 7 | Nicotine also suppressed expressions of BDNF, NT3 and Neuro-D, resulting in decreased bFGF-induced neurite outgrowth. | Nicotine | fibroblast growth factor 2 | Rattus norvegicus |
| 8 | These results indicate that nicotine inhibits bFGF-induced neuronal differentiation in H19-7 cells through inhibition of NO formation by suppressing iNOS/nNOS expressions. | Nicotine | fibroblast growth factor 2 | Rattus norvegicus |