Protein Name fibroblast growth factor 2
Organism Rattus norvegicus
Gene ID 54250
Gene Symbol

Fgf2

UniProt P13109 (FGF2_RAT)
Relationships Total Number of functionally related compound(s) : 785
Total Number of Articles : 1165
Description

fibroblast growth factor 2

Gene Summary

Enables fibroblast growth factor receptor binding activity and histone H3K9me2/3 reader activity. Involved in several processes, including behavioral response to ethanol; positive regulation of cell population proliferation; and regulation of intracellular signal transduction. Acts upstream of or within fibroblast growth factor receptor signaling pathway. Located in extracellular space. Used to study alcohol use disorder and pulmonary hypertension. Biomarker of several diseases, including cocaine abuse; decubitus ulcer; hypertension; middle cerebral artery infarction; and retinal vascular disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including Parkinsonism; corneal neovascularization; diabetic neuropathy; gastric ulcer; and impotence. Orthologous to human FGF2 (fibroblast growth factor 2). [provided by Alliance of Genome Resources, Jul 2025]

synonyms
  • fibroblast growth factor 2
  • HBGF-2
  • angiogenesis promoting growth factor
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Properties